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Moreover, the indole core is substituted at R3 which has a carbonyl group that's also bonded to a napthalene moeity. Napthalene is a bicyclic framework of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it like a ketone. JWH-018 is definitely an analog of THJ-018, where the Main indazole construction is substituted having an indole base. Pharmacology
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Human metabolites ended up equivalent albeit most digestion happened over the indole ring and pentyl aspect chain, as well as the hydroxylated metabolites were commonly fashioned with glucuronide.
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